Supplement given to polo horses incorrectly made, officials say

The Associated Press ~ staff The News
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WEST PALM BEACH, Fla. - Unable to legally bring a supplement into the United States to make their horses more resilient, a Venezuelan polo team used another way to get ready for a champion match: Have a pharmacy mix up the concoction.
What happened next, though, was disastrous. The chemicals were mixed wrong, and 21 horses given the brew died in rapid succession, some collapsing just before taking the field in a championship polo match. The others fell soon after, one by one, shocking a well-heeled crowd gathered to watch the U.S. Open at the International Polo Club Palm Beach in Wellington.
The Lechuza polo team had hoped to get a compound similar to a name-brand supplement used safely around the world to help horses with exhaustion but hasn't been approved by the Food and Drug Administration. Veterinarians commonly turn to compounding pharmacies for medications that can't be found on shelves, but the dispensaries can only recreate unapproved drugs in limited circumstances.
A Florida pharmacy that mixed the medication said Thursday that an internal review found "the strength of an ingredient in the medication was incorrect." Jennifer Beckett, chief operating officer for Franck's Pharmacy in Ocala, Fla., would not say whether the incorrect amount was specified in the order that came from a Florida veterinarian.
Lechuza said the order was for a compound similar to Biodyl, a supplement that includes vitamins and minerals. The team has been using the supplement for many years without problems, but typically uses the manufactured version instead of going to compounding pharmacies.
"Only horses treated with the compound became sick and died within three hours of treatment," Lechuza said in a statement. "Other horses that were not treated remain healthy and normal."
While Biodyl isn't approved in the United States, the supplement made in France by Duluth, Ga.-based animal pharmaceutical firm Merial Ltd. is widely used abroad. The president of the Agentine Equine Veterinarian Association, Fernando Ruiz, said the supplement is commonly used on horses that compete there, and he's not aware of any deaths.
It wasn't clear how closely Franck's mixture came to the name-brand drug, though. Lechuza said what they ordered was supposed to contain vitamin B, potassium, magnesium and selenium, a mineral that can be toxic in high doses.
Compound pharmacies can, among other things, add flavour, make substances into a powder or liquid or remove a certain compound that may have an adverse reaction in different animal species.
FDA spokeswoman Siobhan DeLancey said the agency's interest is now "heightened" with news the deaths could have been caused by a medical mistake at a pharmacy - one that not only produces drugs for animals, but also people.
Florida's State Department of Agriculture and Consumer Services and the Palm Beach County Sheriff's Office are also investigating the deaths, and the pharmacy and polo team said they're co-operating.
20:01ET 23-04-09

Organizations: Food and Drug Administration, U.S. Open, International Polo Club Palm Beach Merial Ltd. Agentine Equine Veterinarian Association State Department of Agriculture and Consumer

Geographic location: United States, Florida, WEST PALM BEACH Wellington Ocala, Fla. France Palm Beach County

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